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Matthew J Fell Selected Research

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

11/2023Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
1/2022Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
1/2016Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

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Matthew J Fell Research Topics

Disease

12Parkinson Disease (Parkinson's Disease)
03/2024 - 12/2015
4Schizophrenia (Dementia Praecox)
03/2012 - 07/2008
3Neurodegenerative Diseases (Neurodegenerative Disease)
11/2023 - 01/2022
3Disease Progression
01/2020 - 01/2017
1Dementia (Dementias)
05/2023
1Sleep Deprivation
01/2020
1Pathologic Processes
03/2012
1Mental Disorders (Mental Disorder)
01/2011
1Central Nervous System Diseases (CNS Diseases)
10/2008
1Psychotic Disorders (Schizoaffective Disorder)
07/2008

Drug/Important Bio-Agent (IBA)

12Phosphotransferases (Kinase)IBA
03/2024 - 12/2015
10Leucine (L-Leucine)FDA Link
03/2024 - 12/2015
3Leucine-Rich Repeat Serine-Threonine Protein Kinase-2IBA
11/2023 - 01/2016
3Glutamic Acid (Glutamate)FDA Link
03/2012 - 07/2008
2Proteins (Proteins, Gene)FDA Link
05/2023 - 01/2020
2Biomarkers (Surrogate Marker)IBA
05/2023 - 01/2020
2LY 2140023IBA
03/2012 - 07/2008
1SynucleinsIBA
05/2023
1Glucosylceramidase (Glucocerebrosidase)IBA
05/2023
1LipidsIBA
05/2023
1rab GTP-Binding ProteinsIBA
01/2016
1Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA
03/2012
1Neurotransmitter Agents (Neurotransmitter)IBA
03/2012
1Glycine Plasma Membrane Transport ProteinsIBA
10/2008
1Phencyclidine (Angel Dust)IBA
07/2008
14- aminho- 2- thiabicyclo(3.1.0)hexane- 4,6- dicarboxylic acidIBA
07/2008
1ProdrugsIBA
07/2008
1HexanesIBA
07/2008
1Dextroamphetamine (Dexedrine)FDA LinkGeneric
07/2008
1Antipsychotic Agents (Antipsychotics)IBA
07/2008
1Adenosine Monophosphate (AMP)IBA
07/2008
1AcidsIBA
07/2008

Therapy/Procedure

4Therapeutics
11/2023 - 01/2017